Metabolomics profiling reveals different patterns in an animal model of asphyxial and dysrhythmic cardiac arrest.

ABSTRACT: Cardiac arrest (CA) is not a uniform condition and its pathophysiology strongly depends on its cause. In this work we have used a metabolomics approach to study the dynamic metabolic changes occurring in the plasma samples of a swine model following two different causes of CA, namely asphyxia (ACA) and ventricular fibrillation (VFCA). Plasma samples were collected at baseline and every minute during the experimental phases. In order to identify the metabolomics profiles characterizing the two pathological entities, all samples were analysed by 1H NMR spectroscopy and LC-MS/MS spectrometry.The metabolomics fingerprints of ACA and VFCA significantly differed during the peri-arrest period and the resuscitation phase. Major alterations were observed in plasma concentrations of metabolites rela

SUBMITTER: Varvarousis D 

PROVIDER: S-EPMC5707403 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature