Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation.

ABSTRACT:

Purpose

Radiation-induced cognitive decline is relatively common after treatment for primary and metastatic brain tumors; however, identifying dosimetric parameters that are predictive of radiation-induced cognitive decline is difficult due to the heterogeneity of patient characteristics. The memory function is especially susceptible to radiation effects after treatment. The objective of this study is to correlate volumetric radiation doses received by critical neuroanatomic structures to post-radiation therapy (RT) memory impairment.

Methods and materials

Between 2008 and 2011, 53 patients with primary brain malignancies were treated with conventionally fractionated RT in prospectively accrued clinical trials performed at our institution. Dose-volume histogram analysis was

SUBMITTER: Okoukoni C 

PROVIDER: S-EPMC5707405 | biostudies-literature | 2017 Oct-Dec

REPOSITORIES: biostudies-literature