Asthmatic Patients with Vitamin D Deficiency have Decreased Exacerbations after Vitamin Replacement.

ABSTRACT:

Background

Intervention studies with vitamin D in asthma are inconclusive for several reasons, such as inadequate dosing or duration of supplementation or uncontrolled baseline vitamin D status. Our aim was to evaluate the benefit of long term vitamin D add-on in asthmatic patients with actual vitamin D deficiency, that is a serum 25-hydroxy vitamin D (25-OHD ) below 20 ng/mL.

Methods

Serum 25-OHD, asthma exacerbations, spirometry and inhaled corticosteroids (CS) dose were evaluated in a cohort of 119 asthmatic patients. Patients with deficiency were evaluated again after one year vitamin supplementation.

Results

25-OHD was low in 111 patients and was negatively related to exacerbations (p < 0.001), inhaled CS dose (p = 0.008) and asthma severity (p</

SUBMITTER: Solidoro P 

PROVIDER: S-EPMC5707706 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature