The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.

ABSTRACT: Microvascular networks in the adventitia of large arteries control access of inflammatory cells to the inner wall layers (media and intima) and thus protect the immune privilege of the aorta and its major branches. In autoimmune vasculitis giant cell arteritis (GCA), CD4 T helper 1 (T_H1) and T_H17 cells invade into the wall of the aorta and large elastic arteries to form tissue-destructive granulomas. Whether the disease microenvironment provides instructive cues for vasculitogenic T cells is unknown. We report that adventitial microvascular endothelial cells (mvECs) perform immunoregulatory functions by up-regulating the expression of the Notch ligand Jagged1. Vascular endothelial growth factor (VEGF), abundantly present in GCA patients' blood, induced Jagged1 express

SUBMITTER: Wen Z 

PROVIDER: S-EPMC5708299 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature