Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.

ABSTRACT: A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6-pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF₅-substituted oxindoles with a range of aldehydes. The resulting products were characterized by X-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.

SUBMITTER: Sansook S 

PROVIDER: S-EPMC5708334 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature