Performance of acoustic radiation force impulse ultrasound imaging for carotid plaque characterization with histologic validation.

ABSTRACT:

Objective

Stroke is commonly caused by thromboembolic events originating from ruptured carotid plaque with vulnerable composition. This study assessed the performance of acoustic radiation force impulse (ARFI) imaging, a noninvasive ultrasound elasticity imaging method, for delineating the composition of human carotid plaque in vivo with histologic validation.

Methods

Carotid ARFI images were captured before surgery in 25 patients undergoing clinically indicated carotid endarterectomy. The surgical specimens were histologically processed with sectioning matched to the ultrasound imaging plane. Three radiologists, blinded to histology, evaluated parametric images of ARFI-induced peak displacement to identify plaque features such as necrotic core (NC), intraplaque hemorrhage (

SUBMITTER: Czernuszewicz TJ 

PROVIDER: S-EPMC5708537 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature