Intramyocellular triacylglycerol accumulation across weight loss strategies; Sub-study of the CENTRAL trial.

ABSTRACT:

Background

Intramyocellular triacylglycerol (IMTG) is utilized as metabolic fuel during exercise and is linked to insulin resistance, but the long-term effect of weight loss strategies on IMTG among participants with abdominal fat, remain unclear.

Methods

In an 18-month trial, sedentary participants with abdominal fat/dyslipidemia were randomized to either a low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet (including 28g·day-1 of walnuts). After 6-months, the participants were re-randomized to moderate intense physical activity (PA+) or non-physical activity (PA-). Magnetic resonance imaging (MRI) was used to quantify changes of IMTG, abdominal sub-depots, hepatic and intermuscular fats.

Results

Across the 277 participants [86% men, age = 48 years, body-ma

SUBMITTER: Gepner Y 

PROVIDER: S-EPMC5708655 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature