Actionable mutations in canine hemangiosarcoma.

ABSTRACT:

Background

Angiosarcomas (AS) are rare in humans, but they are a deadly subtype of soft tissue sarcoma. Discovery sequencing in AS, especially the visceral form, is hampered by the rarity of cases. Most diagnostic material exists as archival formalin fixed, paraffin embedded tissue which serves as a poor source of high quality DNA for genome-wide sequencing. We approached this problem through comparative genomics. We hypothesized that exome sequencing a histologically similar tumor, hemangiosarcoma (HSA), that occurs in approximately 50,000 dogs per year, may lead to the identification of potential oncogenic drivers and druggable targets that could also occur in angiosarcoma.

Methods

Splenic hemangiosarcomas are common in dogs, which allowed us to collect a cohort of archive

SUBMITTER: Wang G 

PROVIDER: S-EPMC5708669 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature