Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection.

ABSTRACT: Periodontal disease is caused by dental plaque biofilms. Fusobacterium nucleatum is an important periodontal pathogen involved in the development of bacterial complexity in dental plaque biofilms. Human gingival fibroblasts (GFs) act as the first line of defense against oral microorganisms and locally orchestrate immune responses by triggering the production of reactive oxygen species and pro-inflammatory cytokines (IL-6 and IL-8). The frequency and severity of periodontal diseases is known to increase in elderly subjects. However, despite several studies exploring the effects of aging in periodontal disease, the underlying mechanisms through which aging affects the interaction between F. nucleatum and human GFs remain unclear. To identify genes affected by infection, aging, or both, we pe

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC5708803 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature