Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) experience high rates of atherosclerotic cardiovascular disease and death that are not fully explained by traditional risk factors. In animal studies, defective cellular cholesterol efflux pathways which are mediated by the ATP binding cassette transporters ABCA1 and ABCG1 are associated with accelerated atherosclerosis. We hypothesized that cholesterol efflux in humans would vary in terms of cellular components, with potential implications for cardiovascular disease.

Methods

We recruited 120 CKD patients (eGFR<30mL/min/1.73m²) and 120 control subjects (eGFR ≥60mL/min/1.73m²) in order to measure cholesterol efflux using either patients' HDL and THP-1 macrophages or patients' monocytes and a flow cyto

SUBMITTER: Ganda A 

PROVIDER: S-EPMC5708851 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature