The polymorphism of rs266729 in adiponectin gene and type 2 diabetes mellitus: A Meta-Analysis.

ABSTRACT: Genome-wide association studies and meta-analyses indicate that the polymorphism of rs266729 in adiponectin gene increases the risk of type 2 diabetes mellitus (T2DM); however, these study methods have not been able to identify the underlying genetic effect on the development of T2DM. A genetic model-free approach was conducted to determine the underlying genetic model of inheritance of T2DM because of rs266729 in adiponectin gene.We searched available studies on the association between the rs266729 in adiponectin gene and T2DM in accordance with the inclusion and exclusion criteria. Based on the information extracted from the studies, generalized odds ratio value (GOR) was used to evaluate whether the rs266729 polymorphism was a risk factor for T2DM. The parameter λ was calculated to esti

SUBMITTER: Sun P 

PROVIDER: S-EPMC5708967 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature