Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.

ABSTRACT: Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We measured this relationship using principal component analyses and methylation-mutation associations applied at the nucleotide level and with respect to genome-wide trends. We found that a few mutated driver genes were associated with genome-wide patterns of aberrant hypomethylation or CpG island hypermethylation in specific cancer types. In addition, we identified associations between 737 mutated driver genes and site-specific methylation changes. Moreover, using these mutation-methylation associations, we were able to distinguish between two

SUBMITTER: Chen YC 

PROVIDER: S-EPMC5709060 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature