CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis.

ABSTRACT: Chronic lymphocytic leukemia (CLL) cells are provided with essential survival and proliferative signals in the lymph node microenvironment. Here, CLL cells engage in various interactions with bystander cells such as T cells and macrophages. Phenotypically distinct types of tumor infiltrating macrophages can either be tumor supportive (M2) or play a role in tumor immune surveillance (M1). Although recent in vitro findings suggest a protective role for macrophages in CLL, the actual balance between these macrophage subsets in CLL lymphoid tissue is still unclear. Furthermore, the mechanism of recruitment of monocytes towards the CLL lymph node is currently unknown. Both questions are addressed in this paper. Immunofluorescence staining of lymph node samples showed macrophage skewing t

SUBMITTER: van Attekum MHA 

PROVIDER: S-EPMC5709106 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature