Blood-based biomarkers for precision medicine in lung cancer: precision radiation therapy.

ABSTRACT: Both tumors and patients are complex and models that determine survival and toxicity of radiotherapy or any other treatment ideally must take into account this variability as well as its dynamic state. The genetic features of the tumor and the host, and increasingly also the epi-genetic and proteomic characteristics, are being unraveled. Multiple techniques, including histological examination, blood sampling, measurement of circulating tumor cells (CTCs), and functional and molecular imaging, can be used for this purpose. However, the effects of radiation on the tumor and on organs at risk (OARs) are also influenced by the applied dose and volume of irradiated tissues. Combining all these biological, clinical, imaging, and dosimetric parameters in a validated prognostic or predictive model

SUBMITTER: De Ruysscher D 

PROVIDER: S-EPMC5709133 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature