Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.

ABSTRACT:

Background

Low tacrolimus concentrations have been associated with higher risk of acute rejection, particularly within African American (AA) kidney transplant recipients; little is known about intrapatient tacrolimus variabilities impact on racial disparities.

Methods

Ten year, single-center, longitudinal cohort study of kidney recipients. Intrapatient tacrolimus variability was assessed using the coefficient of variation (CV) measured between 1 month posttransplant and the clinical event, with a comparable period assessed in those without events. Pediatrics, nontacrolimus/mycophenolate regimens, and nonrenal transplants were excluded. Multivariable Cox regression models were used to analyze data.

Results

One thousand four hundred eleven recipients were included (54.4

SUBMITTER: Taber DJ 

PROVIDER: S-EPMC5709143 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature