The oral microbiota in patients with pancreatic cancer, patients with IPMNs, and controls: a pilot study.

ABSTRACT:

Purpose

Poor oral health appears to be a risk factor for pancreatic cancer, possibly implicating the oral microbiota. In this pilot study, we evaluated the characteristics of the oral microbiota in patients with pancreatic ductal adenocarcinoma (PDAC), intraductal papillary mucinous neoplasms (IPMN), and healthy controls.

Methods

Forty newly diagnosed PDAC patients, 39 IPMN patients, and 58 controls, excluding current smokers and users of antibiotics, provided saliva samples. Common oral bacterial species were comprehensively surveyed by sequencing of the 16S rRNA microbial genes. We obtained measures of diversity and the mean relative proportions of individual taxa. We explored the degree to which these measures differed according to respondent characteristics based on indi

SUBMITTER: Olson SH 

PROVIDER: S-EPMC5709151 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature