Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene.

ABSTRACT:

Aims/hypothesis

Cc2 ^-/- mice lacking the gene encoding the carcinoembryonic-antigen-related cell adhesion molecule 2 (Cc2 [also known as Ceacam2]) exhibit hyperphagia that leads to obesity and insulin resistance. This starts at 2 months of age in female mice. Male mutants maintain normal body weight and insulin sensitivity until the last age previously examined (7-8 months), owing to increased sympathetic tone to white adipose tissue and energy expenditure. The current study investigates whether insulin resistance develops in mutant male mice at a later age and whether this is accompanied by changes in insulin homeostasis.

Methods

Insulin response was assessed by insulin and glucose tolerance tests. Energy balance was analysed by indirect calorimetry.

Results</

SUBMITTER: Ghanem SS 

PROVIDER: S-EPMC5709176 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature