Effects of varenicline on alcohol cue reactivity in heavy drinkers.

ABSTRACT:

Rationale

Clinical trials and human laboratory studies have established that varenicline can reduce rates of alcohol use among heavy drinkers. Less is known about the mechanisms by which varenicline has this effect on drinking behavior. Reactivity to alcohol cues is often cited as the primary cause of relapse among those being treated for alcohol use disorder, and several front-line treatments for alcohol use disorder work, at least in part, by minimizing cue-induced alcohol craving.

Objective

The current double-blind, placebo-controlled human laboratory study tested the effects of varenicline on alcohol cue reactivity in a group of heavy-drinking adult smokers and nonsmokers.

Methods

As part of a larger series of sequential human laboratory experiments testing the ef

SUBMITTER: Roberts W 

PROVIDER: S-EPMC5709183 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature