Metformin and ageing: improving ageing outcomes beyond glycaemic control.

ABSTRACT: In a world where the population is ageing, there is growing interest and demand for research evaluating strategies that address the ageing process. After 60 years of successful use of metformin in our pharmaceutical armamentarium, we are learning that, beyond improving glycaemic control, metformin may have additional mechanisms and pathways of action that need further study. Although, metformin's effect on clinical ageing outcomes may still be considered speculative, the findings from studies into cellular and animal models and from observational and pilot human studies support the existence of beneficial effects on ageing. At present, progress for human research, using randomised clinical trials to evaluate metformin's clinical impact, has just started. Here, we present a review on the ag

SUBMITTER: Valencia WM 

PROVIDER: S-EPMC5709209 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature