Ontology highlight
ABSTRACT:
SUBMITTER: Martin LA
PROVIDER: S-EPMC5709387 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nature communications 20171130 1
Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, endocrine-resistant setting. No naturally occurring ESR1 mutations have been reported in in vitro models of BC either before or after the acquisition of endocrine resistance making functional consequences difficult to study. We report the first discovery of naturally occurring ES ...[more]