Conserved RNA structures in the intergenic regions of ambisense viruses.

ABSTRACT: Ambisense viruses are negative-sense single-stranded RNA viruses that use a unique expression strategy. Their genome contains at least one ambisense RNA segment that carries two oppositely oriented reading frames separated by an intergenic region. It is believed that a structural RNA element within the intergenic region is involved in transcription termination. However, a general overview over the structural repertoire of ambisense intergenic regions is currently lacking. In this study we investigated the structural potential of the intergenic regions of all known ambisense viruses and compared their structural repertoire by structure-guided clustering. Intergenic regions of most ambisense viruses possess a high potential to build stable secondary structures and many viruses share common s

SUBMITTER: Kiening M 

PROVIDER: S-EPMC5709424 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature