Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.

ABSTRACT: Metastatic dissemination of tumor cells is responsible for the fatal outcome of breast cancer. Therefore, understanding the mechanisms involved in dissemination is essential for the development of new therapeutic strategies to prevent metastasis. One mechanism involved in metastatic dissemination of breast cancer cells is dependent on control of the production of matrix metalloproteinases by the neuregulins (NRGs). The NRGs are polypeptide factors that act by binding to the ErbB/HER subfamily of receptor tyrosine kinases. NRG-mediated activation of HER receptors causes an increase in the production of metalloprotease 13 (MMP13, also termed collagenase-3), which facilitates metastatic dissemination of breast tumors. In this context, we aimed to explore whether the clinically approved tyrosi

SUBMITTER: Orive-Ramos A 

PROVIDER: S-EPMC5709617 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature