Aminoquinoline-directed, cobalt-catalyzed carbonylation of sulfonamide sp² C-H bonds.

ABSTRACT: We report a method for cobalt-catalyzed, aminoquinoline-directed sp² C-H bond carbonylation of sulfonamides. The reactions proceed in a dichloroethane solvent, and employ diisopropyl azodicarboxylate as a carbon monoxide source, Mn(OAc)₂ as a cooxidant and potassium pivalate as a base. Halogen, ester, and amide functionalities are compatible with the reaction conditions. This method allows for a short and efficient synthesis of saccharin derivatives.

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC5710005 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature