Heating Pad Performance and Efficacy of 2 Durations of Warming after Isoflurane Anesthesia of Sprague-Dawley Rats (Rattus norvegicus).

ABSTRACT: Anesthetic agents depress thermoregulatory mechanisms, causing hypothermia within minutes of induction of general anesthesia. The consequences of hypothermia include delayed recovery and increased experimental variability. Even when normothermia is maintained during anesthesia, hypothermia may occur during recovery. The primary aim of this study was to identify an effective warming period for maintaining normothermia during recovery. Adult male (n = 8) and female (n = 9) Sprague-Dawley rats were randomized to 30 min (post30) or 60 min (post60) of warming after recovery from anesthesia. During a 40-min anesthetic period, normothermia (target, 37.5 ± 1.1 °C) was maintained by manual adjustment of an electric heating pad in response to measured rectal temperatures (corrected to estimate core

SUBMITTER: Zhang EQ 

PROVIDER: S-EPMC5710158 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature