Association of Genetic Predisposition With Solitary Schwannoma or Meningioma in Children and Young Adults.

ABSTRACT:

Importance

Meningiomas and schwannomas are usually sporadic, isolated tumors occurring in adults older than 60 years and are rare in children and young adults. Multiple schwannomas and/or meningiomas are more frequently associated with a tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas solitary tumors do not. Nevertheless, apparently sporadic tumors in young patients may herald a genetic syndrome.

Objective

To determine the frequency of the known heritable meningioma- or schwannoma-predisposing mutations in children and young adults presenting with a solitary meningioma or schwannoma.

Design, setting, and participants

Using the database of the Manchester Centre for Genomic Medicine, this cohort study analyzed lymphocyte DNA from young indiv

SUBMITTER: Pathmanaban ON 

PROVIDER: S-EPMC5710179 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature