Secular Trends of Amyotrophic Lateral Sclerosis: The Piemonte and Valle d'Aosta Register.

ABSTRACT:

Importance

This study reports the long-term epidemiologic trends of amyotrophic lateral sclerosis (ALS) based on a prospective register.

Objective

To examine the 20-year epidemiologic trends of ALS in the Piemonte and Valle d'Aosta regions of Italy.

Design, setting, and participants

The Piemonte and Valle d'Aosta Register for ALS (PARALS) is an epidemiologic prospective register that covers 2 Italian regions (population of 4 476 931 inhabitants according to the 2011 census) from January 1, 1995, through December 31, 2014. Case ascertainment is based on multiple sources (neurologic departments, hospital discharge archives, and mortality records). Incidence rates are age and sex standardized for the Italian population of the 2011 census. Age-period-cohort (APC) analysis

SUBMITTER: Chio A 

PROVIDER: S-EPMC5710181 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature