Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease.

ABSTRACT:

Importance

Brain hypometabolism is associated with the clinical consequences of the degenerative process, but little is known about regional hypermetabolism, sometimes observed in the brain of patients with clinically manifest Huntington disease (HD). Studying the role of regional hypermetabolism is needed to better understand its interaction with the motor symptoms of the disease.

Objective

To investigate the association between brain hypometabolism and hypermetabolism with motor scores of patients with early HD.

Design, setting, and participants

This study started in 2001, and analysis was completed in 2016. Sixty symptomatic patients with HD and 15 healthy age-matched control individuals underwent positron emission tomography to measure cerebral metabolism in this

SUBMITTER: Gaura V 

PROVIDER: S-EPMC5710184 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature