Genomic Profiling of Small-Bowel Adenocarcinoma.

ABSTRACT:

Importance

Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking.

Objective

To perform in-depth genomic characterization of a large series of SBAs and other gastrointestinal tumors to draw comparisons and identify potentially clinically actionable alterations.

Design, setting, and participants

Prospective analysis was performed of clinical samples from patients with SBA (n = 317), colorectal cancer (n = 6353), and gastric carcinoma (n = 889) collected between August 24, 2012, and February 3, 2016, using hybrid-capture-based genomic profiling, at the request of the individual treating p

SUBMITTER: Schrock AB 

PROVIDER: S-EPMC5710195 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature