Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.

ABSTRACT:

Importance

Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid. Common genetic factors that influence the co-occurrence of MDD and AD have been sought in family, twin, and adoption studies, and results to date have been promising but inconclusive.

Objective

To examine whether AD and MDD overlap genetically, using a polygenic score approach.

Design, settings, and participants

Association analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in European ancestry samples from 4 independent genome-wide association study (GWAS) data sets: the Collaborative Study on the Genetics of Alcoholism (COGA); the Study of Addiction, Genetics, a

SUBMITTER: Andersen AM 

PROVIDER: S-EPMC5710224 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature