Association of White Matter With Core Cognitive Deficits in Patients With Schizophrenia.

ABSTRACT:

Importance

Efforts to remediate the multiple cognitive function impairments in schizophrenia should consider white matter as one of the underlying neural mechanisms.

Objective

To determine whether altered structural brain connectivity is responsible for 2 of the core cognitive deficits in schizophrenia- reduced information processing speed and impaired working memory.

Design, setting, and participants

This cross-sectional study design took place in outpatient clinics from August 1, 2004, to August 31, 2015. Participants included 166 patients with schizophrenia and 213 healthy control individuals. These participants were from 3 independent cohorts, each of which had its own healthy control group. No participant had current or past neurological conditions or major medic

SUBMITTER: Kochunov P 

PROVIDER: S-EPMC5710230 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature