Efficacy of Tramadol Extended-Release for Opioid Withdrawal: A Randomized Clinical Trial.

ABSTRACT:

Importance

Opioid use disorder (OUD) is a significant public health problem. Supervised withdrawal (ie, detoxification) from opioids using clonidine or buprenorphine hydrochloride is a widely used treatment.

Objective

To evaluate whether tramadol hydrochloride extended-release (ER), an approved analgesic with opioid and nonopioid mechanisms of action and low abuse potential, is effective for use in supervised withdrawal settings.

Design, setting, and participants

A randomized clinical trial was conducted in a residential research setting with 103 participants with OUD. Participants' treatment was stabilized with morphine, 30 mg, administered subcutaneously 4 times daily. A 7-day taper using clonidine (n = 36), tramadol ER (n = 36), or buprenorphine (n = 31) was then i

SUBMITTER: Dunn KE 

PROVIDER: S-EPMC5710234 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature