Association of Microvascular Dysfunction With Late-Life Depression: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The etiologic factors of late-life depression are still poorly understood. Recent evidence suggests that microvascular dysfunction is associated with depression, which may have implications for prevention and treatment. However, this association has not been systematically reviewed.

Objective

To examine the associations of peripheral and cerebral microvascular dysfunction with late-life depression.

Data sources

A systematic literature search was conducted in MEDLINE and EMBASE for and longitudinal studies published since inception to October 16, 2016, that assessed the associations between microvascular dysfunction and depression.

Study selection

Three independent researchers performed the study selection based on consensus. Inclusion criteria were a

SUBMITTER: van Agtmaal MJM 

PROVIDER: S-EPMC5710252 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature