Comparative Analysis of Tumor Cell Dissemination to the Sentinel Lymph Nodes and to the Bone Marrow in Patients With Nonmetastasized Colon Cancer: A Prospective Multicenter Study.

ABSTRACT:

Importance

Small nodal tumor infiltrates (SNTI; isolated tumor cells and micrometastases) in sentinel lymph nodes and bone marrow micrometastases (BMM) were independently described as prognostic factors in patients with colon cancer.

Objective

To examine the association between the occurrence of SNTI and BMM as well as their prognostic relevance.

Design, setting, and participants

This prospective study was conducted at 3 university-affiliated institutions in Switzerland between May 2000 and December 2006. Statistical analyses were performed in October 2016. A total of 122 patients with stage I to III colon cancer were included. Follow-up time exceeded 6 years, with no patients lost to follow-up.

Interventions

Bone marrow aspiration from the iliac crests and in

SUBMITTER: Weixler B 

PROVIDER: S-EPMC5710278 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature