Risk of solid cancer in patients with mast cell activation syndrome: Results from Germany and USA.

ABSTRACT: Background:  It has been shown repeatedly that mast cells can promote or prevent cancer development and growth. If development and/or progression of a solid cancer is substantially influenced by mast cell activity, the frequencies of occurrence of solid cancers in patients with primary mast cells disorders would be expected to differ from the corresponding prevalence data in the general population. In fact, a recent study demonstrated that patients with systemic mastocytosis (i.e., a rare neoplastic variant of the primary mast cell activation disease) have increased risk for solid cancers, in particular melanoma and non-melanoma skin cancers. The aim of the present study is to examine whether the risk of solid cancer is increased in systemic mast cell activation syndrome (MCA

SUBMITTER: Molderings GJ 

PROVIDER: S-EPMC5710302 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature