Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease.

ABSTRACT:

Importance

Evidence suggests that development of autonomic dysfunction (AutD) may negatively affect disease course and survival in patients with synucleinopathies. However, the few available studies on Parkinson disease (PD) have conflicting results, comprise a small number of patients, have short follow-up periods, and lack pathologic confirmation of the diagnosis.

Objective

To examine the association of time of onset of AutD with disease progression and survival in PD.

Design, setting, and participants

This retrospective review of clinical data from 100 consecutive patients with an autopsy-confirmed diagnosis of PD from the archives of the Queen Square Brain Bank in London, United Kingdom, from January 1, 2006, to June 3, 2016, included patients with PD regularly se

SUBMITTER: De Pablo-Fernandez E 

PROVIDER: S-EPMC5710320 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature