Skeletal Muscle Involvement in Antisynthetase Syndrome.

ABSTRACT:

Importance

Antisynthetase syndrome, characterized by myositis, interstitial lung disease, skin rash, arthropathy, and Raynaud phenomenon, is a clinical entity based on the presence of aminoacyl transfer RNA synthetase (ARS) antibodies in patients' serum. However, antisynthetase syndrome is not included in the histological subsets of idiopathic inflammatory myopathies.

Objective

To elucidate the clinical features of myositis in patients with antisynthetase syndrome.

Design, setting, and participants

In this cohort study, muscle biopsy and blood samples were collected from 460 patients with idiopathic inflammatory myositis from various regional referral centers throughout Japan between October 2010 and December 2014. Data were analyzed in March 2016.

Exposures

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SUBMITTER: Noguchi E 

PROVIDER: S-EPMC5710328 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature