Association Between Combined TMPRSS2:ERG and PCA3 RNA Urinary Testing and Detection of Aggressive Prostate Cancer.

ABSTRACT:

Importance

Potential survival benefits from treating aggressive (Gleason score, ≥7) early-stage prostate cancer are undermined by harms from unnecessary prostate biopsy and overdiagnosis of indolent disease.

Objective

To evaluate the a priori primary hypothesis that combined measurement of PCA3 and TMPRSS2:ERG (T2:ERG) RNA in the urine after digital rectal examination would improve specificity over measurement of prostate-specific antigen alone for detecting cancer with Gleason score of 7 or higher. As a secondary objective, to evaluate the potential effect of such urine RNA testing on health care costs.

Design, setting, and participants

Prospective, multicenter diagnostic evaluation and validation in academic and community-based ambulatory urology clinics. Participan

SUBMITTER: Sanda MG 

PROVIDER: S-EPMC5710334 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature