The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses : An Individual Participant Meta-analysis.

ABSTRACT:

Importance

The design of infant immunization schedules requires an understanding of the factors that determine the immune response to each vaccine antigen.

Data sources

Deidentified individual participant data from GlaxoSmithKline clinical trials were obtained through Clinical Study Data Request. The data were requested on January 2, 2015, and final data were received on April 11, 2016.

Study selection

Immunogenicity trials of licensed or unlicensed vaccines administered to infants were included if antibody concentrations in infants were measured prior to the first dose of vaccine.

Data extraction and synthesis

The database was examined; studies that appeared to have appropriate data were reviewed.

Main outcomes and measures

Antigen-specific antibody con

SUBMITTER: Voysey M 

PROVIDER: S-EPMC5710349 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature