Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial.

ABSTRACT:

Importance

Major depressive disorder (MDD) is prevalent among patients with chronic kidney disease (CKD) and is associated with morbidity and mortality. The efficacy and adverse events of selective serotonin reuptake inhibitors in these patients are unknown.

Objective

To determine whether treatment with sertraline improves depressive symptoms in patients with CKD and MDD.

Design, setting, and participants

The Chronic Kidney Disease Antidepressant Sertraline Trial (CAST) was a randomized, double-blind, placebo-controlled trial involving 201 patients with stage 3, 4, or 5 non-dialysis-dependent CKD, who were enrolled at 3 US medical centers. The Mini Neuropsychiatric Interview was used to establish MDD. The first participant was randomized in March 2010 and the last cli

SUBMITTER: Hedayati SS 

PROVIDER: S-EPMC5710375 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature