Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery.

ABSTRACT:

Importance

Postsurgical fibrosis is a critical determinant of the long-term success of glaucoma surgery, but no reliable biomarkers are currently available to stratify the risk of scarring.

Objective

To compare the clinical phenotype of patients with conjunctival fibrosis after glaucoma surgery with candidate gene expression tissue biomarkers of fibrosis.

Design, setting, and participants

In this cross-sectional study, 42 patients were recruited at the time of glaucoma surgery at the Moorfields Eye Hospital from September 1, 2014, to September 1, 2016. The participants were divided into those with fibrosis and those without fibrosis.

Main outcomes and measures

Genotype-phenotype correlations of the IL6 or PRG4 gene and detailed clinical phenotype. The IL6 and P

SUBMITTER: Yu-Wai-Man C 

PROVIDER: S-EPMC5710393 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature