Effect of Topical Fluorouracil Cream on Photodamage: Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Photoaging, which is premature skin aging caused by long-term UV exposure, is of aesthetic concern to many patients.

Objective

To investigate the effect of topical fluorouracil, 5%, cream on photoaging using validated photonumeric scales.

Design, setting, and participants

The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized clinical trial of 932 US veterans with a recent history of 2 or more keratinocyte carcinomas performed from September 30, 2011, through June 30, 2014, to assess the chemopreventive effects of a standard course of topical fluorouracil. Photographs were taken at baseline and at numerous time points for up to 4 years. In our secondary analysis, 2 independent dermatologists graded these photographs using 4 valid

SUBMITTER: Korgavkar K 

PROVIDER: S-EPMC5710428 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature