Development and Evaluation of Semiautomated Quantification of Lissamine Green Staining of the Bulbar Conjunctiva From Digital Images.

ABSTRACT:

Importance

Lissamine green (LG) staining of the conjunctiva is a key biomarker in evaluating ocular surface disease. The disease currently is assessed using relatively coarse subjective scales. Objective assessment would standardize comparisons over time and between clinicians.

Objective

To develop a semiautomated, quantitative system to assess lissamine green staining of the bulbar conjunctiva on digital images.

Design, setting, and participants

Using a standard photography protocol, 35 digital images of the conjunctiva of 11 patients with a diagnosis of dry eye disease based on characteristic signs and symptoms were obtained after topical administration of preservative-free LG, 1%, solution. Images were scored independently by 2 masked ophthalmologists in an academi

SUBMITTER: Bunya VY 

PROVIDER: S-EPMC5710489 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature