Quantitative Assessment of Microstructural Changes of the Retina in Infants With Congenital Zika Syndrome.

ABSTRACT:

Importance

A better pathophysiologic understanding of the neurodevelopmental abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treatments. The retina as an extension of the diencephalon accessible to in vivo microcopy with spectral-domain optical coherence tomography (SD-OCT) can provide an insight into the pathophysiology of congenital Zika syndrome (CZS).

Objective

To quantify the microstructural changes of the retina in CZS and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential retinal maldevelopment.

Design, setting, and participants

This case series included 8 infants with CZS and 8 individuals with cblC deficiency. All patients underwent ophthalmologic evaluation at 2 university

SUBMITTER: Aleman TS 

PROVIDER: S-EPMC5710497 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature