Efficacy of Stereotactic Conformal Radiotherapy vs Conventional Radiotherapy on Benign and Low-Grade Brain Tumors: A Randomized Clinical Trial.

ABSTRACT:

Importance

Evidence for application of stereotactic and other conformal radiotherapy techniques in treating brain tumors is largely based on data derived from dosimetric, retrospective, or small prospective studies. Therefore, we conducted a randomized clinical trial of stereotactic conformal radiotherapy (SCRT) compared with conventional radiotherapy (ConvRT) evaluating clinically meaningful end points.

Objective

To compare neurocognitive and endocrine functional outcomes and survival at 5 years in young patients with residual and/or progressive benign or low-grade brain tumors treated with SCRT and ConvRT techniques.

Design, setting, and participants

This phase 3 randomized clinical trial enrolled 200 young patients (ages 3-25 years) with residual or progressive ben

SUBMITTER: Jalali R 

PROVIDER: S-EPMC5710529 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature