Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship.

ABSTRACT:

Importance

Presently, the clinical standard for reporting the results of an amyloid positron emission tomography scan is to assign a dichotomous rating of positive or negative for the presence of amyloid. In a 4-year longitudinal study, we investigated whether using a continuous measure of the magnitude of baseline amyloid burden would provide valuable information about the rate of future cognitive decline over the subsequent 4 years compared with a dichotomous measure in middle-aged and older adults.

Objective

To examine whether a continuous, dose-response relationship between amyloid burden and cognitive decline was present among middle-aged and older adults.

Design, setting, and participants

This cohort study included 174 participants from the Dallas Lifespan Brain

SUBMITTER: Farrell ME 

PROVIDER: S-EPMC5710531 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature