Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

ABSTRACT:

Importance

Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes.

Objectives

To test the hypothesis that there are common genetic risk variants conveying risk of both PD and autoimmune diseases (ie, pleiotropy) and to identify new shared genetic variants and their pathways by applying a novel statistical framework in a genome-wide approach.

Design, setting, and participants

Using the conjunction false discovery rate method, this study analyzed GWAS data from a selection of archetypal autoimmune diseases among 138 511 individuals of Eur

SUBMITTER: Witoelar A 

PROVIDER: S-EPMC5710535 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature