Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration.

ABSTRACT:

Importance

C-reactive protein (CRP) is a circulating inflammatory marker associated with late age-related macular degeneration (AMD). It remains uncertain whether the association between CRP concentrations and AMD is causal.

Objective

To assess whether CRP (OMIM 123260) single-nucleotide polymorphisms that influence circulating CRP concentrations are associated with late AMD.

Design, setting, and participants

Participants in 2 UK, hospital-based, case-control studies (Cambridge AMD study and Moorfields Eye Hospital AMD study) and 1 pan-European, cross-sectional, population-based study (the European Eye [EUREYE] Study) were recruited between November 6, 2000, and April 30, 2007. Participants underwent dilated stereo-digital fundus photography graded according to the In

SUBMITTER: Cipriani V 

PROVIDER: S-EPMC5710541 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature