Placebo Response and Practice Effects in Schizophrenia Cognition Trials.

ABSTRACT:

Importance

Patients' previous experience with performance-based cognitive tests in clinical trials for cognitive impairment associated with schizophrenia can create practice-related improvements. Placebo-controlled trials for cognitive impairment associated with schizophrenia are at risk for these practice effects, which can be difficult to distinguish from placebo effects.

Objectives

To conduct a systematic evaluation of the magnitude of practice effects on the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB) in cognitive impairment associated with schizophrenia and to examine which demographic, clinical, and cognitive characteristics were associated with improvement in placebo conditions.

Design, setting, and pa

SUBMITTER: Keefe RSE 

PROVIDER: S-EPMC5710557 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature