ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak.

ABSTRACT: Mitochondrial distribution and motility are recognized as central to many cellular functions, but their regulation by signaling mechanisms remains to be elucidated. Here, we report that reactive oxygen species (ROS), either derived from an extracellular source or intracellularly generated, control mitochondrial distribution and function by dose-dependently, specifically, and reversibly decreasing mitochondrial motility in both rat hippocampal primary cultured neurons and cell lines. ROS decrease motility independently of cytoplasmic [Ca²⁺], mitochondrial membrane potential, or permeability transition pore opening, known effectors of oxidative stress. However, multiple lines of genetic and pharmacological evidence support that a ROS-activated mitogen-activated protein kinase (MAP

SUBMITTER: Debattisti V 

PROVIDER: S-EPMC5710826 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature