Phenotypic and clinical characterization of low density neutrophils in patients with advanced lung adenocarcinoma.

ABSTRACT:

Purpose

An immunosuppressive subgroup of neutrophils, low density neutrophils (LDNs) was reported to be closely related to several diseases. This study was designed to explore the association between LDNs and advanced lung adenocarcinoma, as well as potential mechanisms.

Results

The expression levels of surface CD molecules on LDNs were different from high density neutrophils (HDNs), consistent with previous studies. The ratio of LDNs/HDNs, rather than the percentage of LDNs in peripheral blood mononuclear cells (PBMCs), was significantly higher in lung adenocarcinoma patients than healthy controls. It was also observed that the ratio decreased when patients received anti-cancer treatments, and increased when disease relapsed. Patients harboring positive epidermal growth fac

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5710898 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature